Faculty Details

Dr. Subhash Chandra Yadav

Designation: Assistant Professor

Email ID: subhashmbu@gmail.com; subhashmbu@aiims.gov.in

Contact No: 011-26549127

Address: UG 12, Basement (-1), Convergence Block; Electron Microscope Facility, Department of Anatomy, All India Institute of Medical Sciences, New Delhi 110029

  • Profile
  • Research
  • Publication
  • Lab Members

Profile

Dr. Subhash Chandra Yadav received his MSc. in Biotechnology (2003) and PhD (2007) in Molecular Biology from Banaras Hindu University (BHU), Varanasi, India. He was visiting researcher at Institute of Crystallography, Free University (FU) Berlin Germany during 2005-06. He was postdoctoral fellow at Molecular Biophysics Unit, Indian Institute of Science (IISc), Bangalore Karnataka (2007-08) India and Medical Center, University of Tennessee Knoxville TN USA (2008). He worked as Scientist In charge of Nanobiology and electron microscopy facility at Institute of Himalayan Bioresource Technology (CSIR-IHBT) Palampur H.P. India from August 2008 to November 2011. He was employed as Fellow and subsequently became area convener at TERI-Deakin Nanobiotechnology Centre (TDNBC), New Delhi from 2011 to 2015. He joined Department of Anatomy, AIIMS as Assistant Professor in Electron Microscopy and Nanotechnology in June 2015.




Research

Research interest:

Development of nanotechnology based diagnostics system, Targeted drug delivery vehicles and therapeutic efficacy improvement of biomolecules.

Publication


Research Papers: (22) Total Impact Factor (60.517) 
Total Citation -2208: i10= 14; h-index= 12

i.Indu Barwal, Rajiv Kumar, Suneel Kateriya, Amit Dinda, Subhash C Yadav*: Targeted delivery system for cancer cells consist of multiple ligands conjugated genetically modified CCMV capsid on doxorubicin GNPs complex. Nature Scientific Report, (Accepted) 2016

IF: 5.224Citation: 0 

ii. M Tiwary, N Agarwal, A Dinda, Subhash C Yadav*Overexpression and purification of folded domain of prostate cancer related proteins MSMB and PSA, Molecular Biology Reports, 2016 1-10

IF: 2.024Citation: 1 

iii.Shalini Gour, Vibha Kaushik, Vijay Kumar, Priyanka Bhat, Subhash C. Yadav and Jay K. Yadav Antimicrobial peptide (Cn-AMP2) from liquid endosperm of Cocos nucifera forms amyloid-like fibrillar structure Journal of Peptide Science Volume 22, Issue 4, pages 201–207, April 2016

IF: 1.546Citation: 2 

iv. Neetu Sharma, Vishwanath Sivalingam, Sonalika Maurya, Archana Prasad, Puneet Khandelwal, Subhash Chandra Yadav, B.K. Patel New insights into in vitro amyloidogenic properties of human serum albumin suggest considerations for therapeutic precautions FEBS Letters 589 (2015) 1873-3468

IF: 3.169Citation: 3 

v. Dewei Jia, Indu Barwal, Shloka Thakur, Subhash C. Yadav*. Methodology to nanoencapsulate hepatoprotective components from Picrorhiza kurroa as food supplement, Food Biosciences, Volume 9, 1 March 2015, Pages 28–35; IF: 0.995Citation: 4 

vi.Indu Barwal, Subhash C Yadav*Rebaudioside A Loaded PLA-Nanoparticles as an Anti-diabetic Nanomedicine, Journal of Bionanosciences; Volume 8, Number 2, April 2014, pp. 137-140 IF: NACitation: 10 

vii.Pavan Sunkireddy, Shashi Nath Jha, Jagat R. Kanwar, Subhash C. Yadav*. Natural Antioxidant Biomolecules Promises Future Nanomedicine Based Therapy for Cataract, Colloids and Surfaces B: Biointerfaces 2013; 112: 554562 IF: 4.152, Citation: 24 

viii. Ashok Kumar Yadav, S Singh, Subhash C Yadav, D Dhyani, Garima Bhardwaj, Anjali Sharma Bikram Singh. Induction and morpho-chemical characterization of Stevia rebaudiana colchiploids, Indian Journal of Agricultural Sciences 2013; 83 (2): 159–65. IF: 0.170, Citation: 5 

ix.Indu Barwal, Anil Sood, Mohit Sharma, Bikram Singh, Subhash C Yadav* Development of stevioside pluronic f-68 copolymer PLA-nanoparticles as an antidiabetic nanomedicine, Colloids and Surfaces B: Biointerfaces 2013; 10: 510-6. IF: 4.152, Citation: 23

x.Indu Barwal, Peeyush Ranjan, Suneel Kateriya, Subhash C Yadav*; Cellular oxido-reductive proteins of Chlamydomonas reinhardtii control the biosynthesis of silver nanoparticles in vitro and in vivo, Journal of Nanobiotechnology, 2011, 9:56 doi:10.1186/1477-3155-9-56; IF: 4.115Citation: 38

xi. Subhash C Yadav*, Sudesh K Yadav, Anil Sood, Mohit Sharma, Bikram SinghDevelopment of Antidiabetic Nanomedicine from Stevioside, Journal of Biomedical Nanotechnology, 2011, Feb 7;(1):54-55; IF: 5.338, Citation: 4

xii. Subhash C Yadav*, Kumari A, Yadav R. Development of peptide and protein nanotherapeutics by nanoencapsulation and nanobioconjugation. Peptides. 2011 Jan;32(1):173-87. IF: 2.618, Citation: 81 

xiii. Avnesh Kumari, Sudesh Kumar Yadav, Yogesh B. Pakade, Vineet Kumar, Bikram Singh, Abha Chaudhary, and Subhash C Yadav*. Nanoencapsulation and characterization of Albizia chinensis isolated antioxidant quercitrin on PLA nanoparticles, 
Colloids and Surfaces B: Biointerfaces 2011 Jan 1;82(1):224-32 
IF: 4.152, Citation: 73 

xiv. Subhash C Yadav*, NK Prasanna Kumari, M V Jagannadham. Deglycosylated milin unfolds via inactive monomeric intermediates. European Journal of Biophysics 2010 Nov;39(12):1581-8. IF: 2.219, Citation: 0

xv. Avnesh Kumari, Yogesh B. Pakade, Bikram Singh, Sudesh Kumar Yadav and Subhash C Yadav*. Development of biodegradable nanoparticles for delivery of quercetinColloid and Surface Chemistry B, 2010, 80, 184-192 IF: 4.152, Citation: 148

xvi. Subhash C Yadav*, Jagannadham MV, Suman Kundu. Equilibrium unfolding of kinetically stable protein milin: Presence of active dimeric intermediates and sequential unraveling of different layers. European Journal of Biophysics 2010 Sep;39(10):1385-96,  IF: 2.219, Citation: 06

xvii. Avnesh Kumari, Sudesh Kumar Yadav, Subhash C Yadav*- Biodegradable polymeric nanoparticles based drug delivery systems. Colloid and Surface Chemistry B (2010) 75, 1-18 IF: 4.152Citation: 1492 (Most Cited paper of the Journal)

xviii.Vineet Kumar, Subhash C YadavSudesh Kumar Yadav*, Syzygium cumini leaf and seed extract mediated biosynthesis of silver nanoparticles and their characterization. J. Chem. Techonol, Biotechnol 2010; 85: 1301–1309 IF: 2.349, Citation: 133

xix. Subhash C Yadav *, Jagannadham MV. Complete conformational stability of kinetically stable dimeric serine protease milin against pH, temperature, urea and proteolysis. European Journal of Biophysics (2009) 38, 981-991 IF: 2.219, Citation: 11

xx. Subhash C YadavMV Jagannadham, Suman Kundu, Medicherla V. Jagannadham. A kinetically stable plant subtilase with unique peptide mass fingerprints and dimerization properties. Biophysical Chemistry, (2009) 139, 13-23 IF: 1.986, Citation: 12

xxi. Subhash C Yadav, Jagannadham MV. Physiological changes and molluscicidal effects of crude latex and Milin on Biomphalaria glabrata.Chemosphere. 2008 Apr;71(7): 1295-300. IF: 3.340, Citation: 13

xxii. Pande M, Dubey VK, Subhash C Yadav, Jagannadham MV. A novel serine protease cryptolepain from Cryptolepis buchanani: purification and biochemical characterization. J Agric Food Chem. 2006 Dec 27;54(26):10141-50. IF: 2.912, Citation: 50

xxiii. Subhash C Yadav, Pande M, Jagannadham MV. Highly stable glycosylated serine protease from the medicinal plant Euphorbia milii. Phytochemistry. 2006 Jul;67(14):1414-26. IF: 2.547Citation: 75

*     Corresponding Author



Patent Filed

(i)             Cancer Detection System: Mohini Tiwary, Madhu Bakka, Amit Dinda, Subhash C Yadav,. Indian Patent (201611011074/2014)

(ii)           Novel Chitosan based Nanoparticles/ultra-nanoparticles and Method for the preparation of same. Subhash C Yadav*, Pavan Sunkireddy, Chandrakant Tripathi, Alok Adholeya; Indian Patent (IN 3060/DEL/2013)

(iii)          A conjugate comprising gold nanoparticles and Venturia inaequalis specific probes and kits comprising the same for the detection of apple scab; Pramila, Ashish Bedi, Gopaljee Jha, Subhash C Yadav. Indian patent: IN Patent 1361/DEL/2,015


Invited Talk

                                        i.     Chimeric drug delivery system from plant virus capsid protein (2016), NanoBio Interface, (International Symposium), at School of Biotechnology, JNU New Delhi, March 18-20,

                                       ii.     Development of nanoparticulate based chimeric drug delivery system using drug bio-conjugated plant virus capsids on biocompatible nanoparticles (2015), XIII International Conference on Biomaterials, Colloids, and nanomedicine (ICBCN 2015), at Paris France dated 23-24 January 2015

                                     iii.     Development of nanoparticulate based chimeric drug delivery system using drug bio-conjugated plant virus capsids on biocompatible nanoparticles” (2014), Australia India Strategic research funds conference on Bio/Nanotechnology applications to improve plant productivity and ecosystems services.”  at Deakin University, Geelong Melbourne Australia on 11-14 march 2014.

                                     iv.     Therapeutic Potential Improvement of Natural Antioxidants through Nanotechnological Intervention (2013) International conference on Nanomedicine” at New Delhi, India on 30-31 May 2013.

                                       v.     Antidiabetic nanomedicine from Stevioside (2012) Deakin India Research Initiative International Symposium New Delhi (November 28-30)

                                     vi.     Molecular Mechanism of Plant Cell/Extract Mediated Silver Nanoparticle Biosynthesis (2012) DIPAS New Delhi (September 27)

                                    vii.     Use of Nanotechnology for Resolving Challenges in Agricultural and Biomedical Issues (2012) International Technology program (ITECH) (Aug 17)

                                  viii.     Molecular Mechanism of Plant mediated biosynthesis of silver nanoparticles (2011) International symposium on “Frontier in Science” at TERI, New Delhi (22-24 November)

                                      ix.     Development of antidiabetic Nanomedicine from Stevioside (2011), International Symposium on The Safe Use of Nanomaterials at Indian Institute of Toxicology Research, Lucknow (February 1-3)

                                       x.     Proteins from medicinally important plants: Functional and Structural perspective (2009) at National Symposium on Cellular and Molecular Biophysics, Under the aegis of The Indian Biophysical Society, held at CCMB, Hyderabad, India

                                      xi.     Development of nanomedicine of antioxidant quercitrin biomolecules with PLA nanoparticles (2009) Summer School and workshop at NIPER Mohali Punjab

                  

Lab Members

Dr. Abhishek Gupta (National Post Doctoral Fellow)

Project Title: Visual, Rapid, Non-invasive and Cost-effective BK Virus Detection System for Renal Transplanted Patients using Gold Nanoparticle Coupled Loop mediated Isothermal Amplification (Nano-LAMP)

Onsite, quick, sensitive and visual detection of BK virus before and after the renal transplant may reduce the chances of infection based rejection of the graft. He work on the  development of Nano-LAMP based detection system of the same virus. This test can be used for directs diagnosis for critical care to timely utilize the preventive medicine to reduce the graft failure. Simple two-step, low cost and quick (1-2 hours/test) detection would provide the advantage over the currently used diagnostic methodology and may change the paradigm for polyoma virus infection based failure of renal transplant.